Version 5.4
Homo sapiens Protein: SULT1B1
Summary
InnateDB Protein IDBP-21924.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SULT1B1
Protein Name sulfotransferase family, cytosolic, 1B, member 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000308770
InnateDB Gene IDBG-21922 (SULT1B1)
Protein Structure
UniProt Annotation
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine. {ECO:0000269PubMed:9443824, ECO:0000269PubMed:9463486}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in the liver, peripheral blood leukocytes, colon (mucosal lining), small intestine (jejunum) and spleen. A lesser expression was observed in the lung, placenta and thymus. {ECO:0000269PubMed:9463486}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004062 aryl sulfotransferase activity
GO:0008146 sulfotransferase activity
Biological Process
GO:0006576 cellular biogenic amine metabolic process
GO:0006805 xenobiotic metabolic process
GO:0008152 metabolic process
GO:0008202 steroid metabolic process
GO:0009812 flavonoid metabolic process
GO:0018958 phenol-containing compound metabolic process
GO:0030855 epithelial cell differentiation
GO:0042403 thyroid hormone metabolic process
GO:0044281 small molecule metabolic process
GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0051923 sulfation
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000863 Sulfotransferase domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00685
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43704
PhosphoSite PhosphoSite-O43704
TrEMBL D6RIA8
UniProt Splice Variant
Entrez Gene 27284
UniGene Hs.129742
RefSeq NP_055280
HUGO HGNC:17845
OMIM 608436
CCDS CCDS3530
HPRD 07088
IMGT
EMBL AC108941 AC125239 AF184894 BC010895 D89479 U95726
GenPept AAB65154 AAF05917 AAH10895 BAA24547

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca