InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GTF3C1

Summary

InnateDB Protein

IDBP-21914.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GTF3C1

Protein Name

general transcription factor IIIC, polypeptide 1, alpha 220kDa

Synonyms

TFIIIC; TFIIIC220; TFIIICalpha;

Species

Homo sapiens

Ensembl Protein

ENSP00000348510

InnateDB Gene

IDBG-21912 (GTF3C1)

Protein Structure

UniProt Annotation

Function

Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	66 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006383	transcription from RNA polymerase III promoter
GO:0009303	rRNA transcription
GO:0009304	tRNA transcription
GO:0010467	gene expression
GO:0042791	5S class rRNA transcription from RNA polymerase III type 1 promoter
GO:0042797	tRNA transcription from RNA polymerase III promoter

Cellular Component

GO:0000127	transcription factor TFIIIC complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex