InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TEP1

Summary

InnateDB Protein

IDBP-2185.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TEP1

Protein Name

telomerase-associated protein 1

Synonyms

p240; TLP1; TP1; TROVE1; VAULT2;

Species

Homo sapiens

Ensembl Protein

ENSP00000262715

InnateDB Gene

IDBG-2183 (TEP1)

Protein Structure

UniProt Annotation

Function

Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi- subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}. Chromosome, telomere.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:9020079}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003720	telomerase activity
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0000722	telomere maintenance via recombination
GO:0006278	RNA-dependent DNA replication

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0005697	telomerase holoenzyme complex
GO:0005737	cytoplasm
GO:0016363	nuclear matrix
GO:0030529	ribonucleoprotein complex

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR007111 NACHT nucleoside triphosphatase
IPR008850 TEP1, N-terminal
IPR008858 TROVE
IPR017986 WD40-repeat-containing domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00400
PF05386
PF05731

PRINTS

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99973