InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KAT2B

Summary

InnateDB Protein

IDBP-21807.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KAT2B

Protein Name

K(lysine) acetyltransferase 2B

Synonyms

CAF; P/CAF; PCAF;

Species

Homo sapiens

Ensembl Protein

ENSP00000263754

InnateDB Gene

IDBG-21805 (KAT2B)

Protein Structure

UniProt Annotation

Function

Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. {ECO:0000269PubMed:10675335, ECO:0000269PubMed:14645221, ECO:0000269PubMed:23932781, ECO:0000269PubMed:8684459, ECO:0000269PubMed:9707565}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed but most abundant in heart and skeletal muscle. {ECO:0000269PubMed:8684459}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 218 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	218 [view]
Protein-Protein	206 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0004468	lysine N-acetyltransferase activity
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515	protein binding
GO:0008080	N-acetyltransferase activity
GO:0008134	transcription factor binding
GO:0016407	acetyltransferase activity
GO:0019901	protein kinase binding
GO:0032403	protein complex binding
GO:0042826	histone deacetylase binding

Biological Process

GO:0006325	chromatin organization
GO:0006338	chromatin remodeling
GO:0006355	regulation of transcription, DNA-templated
GO:0006360	transcription from RNA polymerase I promoter
GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006473	protein acetylation
GO:0007050	cell cycle arrest
GO:0007219	Notch signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0010467	gene expression
GO:0010835	regulation of protein ADP-ribosylation
GO:0016032	viral process
GO:0016573	histone acetylation
GO:0018076	N-terminal peptidyl-lysine acetylation
GO:0018393	internal peptidyl-lysine acetylation
GO:0018394	peptidyl-lysine acetylation
GO:0032869	cellular response to insulin stimulus
GO:0043966	histone H3 acetylation
GO:0043970	histone H3-K9 acetylation
GO:0045087	innate immune response (InnateDB)
GO:0045722	positive regulation of gluconeogenesis
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048511	rhythmic process

Cellular Component

GO:0000123	histone acetyltransferase complex
GO:0000125	PCAF complex
GO:0000776	kinetochore
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex
GO:0031672	A band
GO:0031674	I band
GO:0042641	actomyosin