InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UGT2B7

Summary

InnateDB Protein

IDBP-21727.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UGT2B7

Protein Name

UDP glucuronosyltransferase 2 family, polypeptide B7

Synonyms

UDPGT 2B9; UDPGT2B7; UDPGTH2; UGT2B9;

Species

Homo sapiens

Ensembl Protein

ENSP00000304811

InnateDB Gene

IDBG-21725 (UGT2B7)

Protein Structure

UniProt Annotation

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. {ECO:0000269PubMed:17442341}.Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro). {ECO:0000269PubMed:17442341}.

Subcellular Localization

Microsome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015020	glucuronosyltransferase activity
GO:0016758	transferase activity, transferring hexosyl groups
GO:0030246	carbohydrate binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006629	lipid metabolic process
GO:0008152	metabolic process
GO:0008209	androgen metabolic process
GO:0030259	lipid glycosylation
GO:0052695	cellular glucuronidation