InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CKB

Summary

InnateDB Protein

IDBP-21615.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CKB

Protein Name

creatine kinase, brain

Synonyms

B-CK; BCK; CKBB; HEL-211; HEL-S-29;

Species

Homo sapiens

Ensembl Protein

ENSP00000299198

InnateDB Gene

IDBG-21613 (CKB)

Protein Structure

UniProt Annotation

Function

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	59 [view]
Protein-Protein	59 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004111	creatine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006600	creatine metabolic process
GO:0007420	brain development
GO:0016310	phosphorylation
GO:0021762	substantia nigra development
GO:0030644	cellular chloride ion homeostasis
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process