InnateDB Protein
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IDBP-21043.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RANBP3
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Protein Name
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RAN binding protein 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000034275
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InnateDB Gene
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IDBG-21037 (RANBP3)
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Protein Structure
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Function |
Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF- beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269PubMed:11425870, ECO:0000269PubMed:11571268, ECO:0000269PubMed:11932251, ECO:0000269PubMed:19289081, ECO:0000269PubMed:9637251}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:19289081}. Nucleus {ECO:0000269PubMed:19289081}.
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Disease Associations |
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Tissue Specificity |
Widely expressed with high levels in testis and heart. {ECO:0000269PubMed:9637251}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
42
[view]
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Protein-Protein |
37
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
2
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000156
Ran binding domain
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PFAM |
PF00638
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PRINTS |
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PIRSF |
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SMART |
SM00160
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H6Z4
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PhosphoSite |
PhosphoSite-Q9H6Z4
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TrEMBL |
K7ESQ0
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UniProt Splice Variant |
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Entrez Gene |
8498
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UniGene |
Hs.619115
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RefSeq |
NP_015559
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HUGO |
HGNC:9850
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OMIM |
603327
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CCDS |
CCDS42477
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HPRD |
04508
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IMGT |
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EMBL |
AC004602
AC005784
AC093050
AC104532
AK025300
AK314343
AL050149
BC004349
Y08697
Y08698
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GenPept |
AAC14485
AAH04349
BAB15106
BAG36985
CAA69956
CAA69957
CAB43293
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