Version 5.4
Homo sapiens Protein: RANBP3
Summary
InnateDB Protein IDBP-21041.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RANBP3
Protein Name RAN binding protein 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000341483
InnateDB Gene IDBG-21037 (RANBP3)
Protein Structure
UniProt Annotation
Function Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF- beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269PubMed:11425870, ECO:0000269PubMed:11571268, ECO:0000269PubMed:11932251, ECO:0000269PubMed:19289081, ECO:0000269PubMed:9637251}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:19289081}. Nucleus {ECO:0000269PubMed:19289081}.
Disease Associations
Tissue Specificity Widely expressed with high levels in testis and heart. {ECO:0000269PubMed:9637251}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
Experimentally validated
Total 42 [view]
Protein-Protein 37 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008536 Ran GTPase binding
GO:0070412 R-SMAD binding
Biological Process
GO:0015031 protein transport
GO:0046907 intracellular transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000156 Ran binding domain
PFAM PF00638
PRINTS
PIRSF
SMART SM00160
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H6Z4
PhosphoSite PhosphoSite-Q9H6Z4
TrEMBL K7ESQ0
UniProt Splice Variant
Entrez Gene 8498
UniGene Hs.619115
RefSeq NP_015561
HUGO HGNC:9850
OMIM 603327
CCDS CCDS42478
HPRD 04508
IMGT
EMBL AC004602 AC005784 AC093050 AC104532 AK025300 AK314343 AL050149 BC004349 Y08697 Y08698
GenPept AAC14485 AAH04349 BAB15106 BAG36985 CAA69956 CAA69957 CAB43293

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca