InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IFNAR1

Summary

InnateDB Protein

IDBP-2099.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFNAR1

Protein Name

interferon (alpha, beta and omega) receptor 1

Synonyms

AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC;

Species

Homo sapiens

Ensembl Protein

ENSP00000270139

InnateDB Gene

IDBG-2095 (IFNAR1)

Protein Structure

UniProt Annotation

Function

Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta- subunits themselves. Can also transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.

Subcellular Localization

Isoform 1: Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. {ECO:0000269PubMed:8307198}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	34 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004904	interferon receptor activity
GO:0004905	type I interferon receptor activity
GO:0005515	protein binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007259	JAK-STAT cascade
GO:0009615	response to virus
GO:0019221	cytokine-mediated signaling pathway
GO:0032729	positive regulation of interferon-gamma production
GO:0042110	T cell activation
GO:0045087	innate immune response (InnateDB)
GO:0045351	type I interferon biosynthetic process
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0051607	defense response to virus
GO:0060337	type I interferon signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway