InnateDB Protein
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IDBP-209577.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Eif3c
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Protein Name
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eukaryotic translation initiation factor 3, subunit C
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Synonyms
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110kDa; 3230401O13Rik; Eif3s8; NIPIL(A3); NipilA3; Xs; Xsl;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000032992
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InnateDB Gene
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IDBG-209573 (Eif3c)
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Protein Structure
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Function |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
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Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03002}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
74 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
GO:0005852
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eukaryotic translation initiation factor 3 complex
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GO:0016282
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eukaryotic 43S preinitiation complex
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GO:0033290
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eukaryotic 48S preinitiation complex
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GO:0071541
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eukaryotic translation initiation factor 3 complex, eIF3m
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PDB ID |
MGI:1926966
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InterPro |
IPR000717
Proteasome component (PCI) domain
IPR008905
Eukaryotic translation initiation factor 3 subunit C, N-terminal domain
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PFAM |
PF01399
PF05470
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PRINTS |
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PIRSF |
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SMART |
SM00088
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TIGRFAMs |
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Modification |
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SwissProt |
Q8R1B4
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PhosphoSite |
PhosphoSite-Q8R1B4
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TrEMBL |
Q9CV26
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UniProt Splice Variant |
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Entrez Gene |
56347
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UniGene |
Mm.401564
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RefSeq |
NP_666312
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MGI ID |
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MGI Symbol |
Eif3c
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OMIM |
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CCDS |
CCDS21832
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HPRD |
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IMGT |
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EMBL |
AK009925
AK160078
AK166743
BC024855
BC025032
BC080763
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GenPept |
AAH24855
AAH25032
AAH80763
BAB26588
BAE35610
BAE38985
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