Version 5.4
Homo sapiens Protein: PLBD1
Summary
InnateDB Protein IDBP-20956.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLBD1
Protein Name phospholipase B domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000240617
InnateDB Gene IDBG-20954 (PLBD1)
Protein Structure
UniProt Annotation
Function In view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity). Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids. {ECO:0000250, ECO:0000269PubMed:19019078}.
Subcellular Localization Lysosome {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in neutrophils and monocytes. {ECO:0000269PubMed:19019078}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0016042 lipid catabolic process
GO:0036149 phosphatidylinositol acyl-chain remodeling
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005764 lysosome
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR007000 Phospholipase B-like
PFAM PF04916
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P4A8
PhosphoSite PhosphoSite-Q6P4A8
TrEMBL F5H053
UniProt Splice Variant
Entrez Gene 79887
UniGene Hs.131933
RefSeq NP_079105
HUGO HGNC:26215
OMIM
CCDS CCDS31751
HPRD 08660
IMGT
EMBL AC008114 AK026315 AK290914 BC000909 BC063561
GenPept AAH00909 AAH63561 BAB15442 BAF83603

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca