InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GZMA

Summary

InnateDB Protein

IDBP-20852.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GZMA

Protein Name

granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)

Synonyms

CTLA3; HFSP;

Species

Homo sapiens

Ensembl Protein

ENSP00000274306

InnateDB Gene

IDBG-20850 (GZMA)

Protein Structure

UniProt Annotation

Function

Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. {ECO:0000269PubMed:11555662, ECO:0000269PubMed:12524539, ECO:0000269PubMed:12628186, ECO:0000269PubMed:16818237}.

Subcellular Localization

Isoform alpha: Secreted. Cytoplasmic granule.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	33 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0006955	immune response
GO:0019835	cytolysis
GO:0032078	negative regulation of endodeoxyribonuclease activity
GO:0043065	positive regulation of apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0051354	negative regulation of oxidoreductase activity
GO:0051603	proteolysis involved in cellular protein catabolic process