InnateDB Protein
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IDBP-207525.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Fscn1
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Protein Name
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fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)
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Synonyms
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AI663989; Fan1; fascin-1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000031565
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InnateDB Gene
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IDBG-207523 (Fscn1)
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Protein Structure
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Function |
Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, invadopodium {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Most abundant in brain. Found in other tissues including uterus, small intestine and spleen.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
41 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1352745
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InterPro |
IPR008999
Actin cross-linking
IPR022768
Fascin domain
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PFAM |
PF06268
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q61553
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PhosphoSite |
PhosphoSite-Q61553
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TrEMBL |
D3Z1X1
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UniProt Splice Variant |
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Entrez Gene |
14086
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UniGene |
Mm.289707
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RefSeq |
NP_032010
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MGI ID |
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MGI Symbol |
Fscn1
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OMIM |
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CCDS |
CCDS19834
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HPRD |
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IMGT |
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EMBL |
AC144818
AK167670
BC010338
BC037137
BC052408
L33726
U90355
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GenPept |
AAB41126
AAB58784
AAH10338
AAH37137
AAH52408
BAE39719
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