InnateDB Protein
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IDBP-20554.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GPRC5A
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Protein Name
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G protein-coupled receptor, family C, group 5, member A
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Synonyms
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GPCR5A; RAI3; RAIG1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000014914
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InnateDB Gene
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IDBG-20552 (GPRC5A)
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Protein Structure
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Function |
Unknown. This G-protein coupled receptor could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. The comparable expression level in fetal lung and kidney with adult tissues suggests a possible role in embryonic development and maturation of these organs. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways.
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Subcellular Localization |
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localized in the plasma membrane and perinuclear vesicles.
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Disease Associations |
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Tissue Specificity |
Expressed at high level in fetal and adult lung tissues. Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259, expressed at low but detectable level in pancreas and heart. {ECO:0000269PubMed:10783259, ECO:0000269PubMed:10945465}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004930
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G-protein coupled receptor activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR017978
GPCR, family 3, C-terminal
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PFAM |
PF00003
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8NFJ5
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PhosphoSite |
PhosphoSite-Q8NFJ5
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TrEMBL |
F5GWG3
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UniProt Splice Variant |
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Entrez Gene |
9052
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UniGene |
Hs.735417
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RefSeq |
NP_003970
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HUGO |
HGNC:9836
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OMIM |
604138
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CCDS |
CCDS8657
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HPRD |
16037
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IMGT |
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EMBL |
AC007688
AF095448
AF506289
AK001761
AK122672
BC003665
CH471094
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GenPept |
AAC98506
AAH03665
AAM77594
BAA91890
BAG53657
EAW96289
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