InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DUSP16

Summary

InnateDB Protein

IDBP-20240.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUSP16

Protein Name

dual specificity phosphatase 16

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000298573

InnateDB Gene

IDBG-20236 (DUSP16)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0043409	negative regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0045204	MAPK export from nucleus
GO:0045209	MAPK phosphatase export from nucleus, leptomycin B sensitive

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016023	cytoplasmic membrane-bounded vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR001763 Rhodanese-like domain
IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00782
PF00581

PRINTS

PR01764

PIRSF

PIRSF000939

SMART

SM00450
SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References