Version 5.4
Homo sapiens Protein: DUSP16
Summary
InnateDB Protein IDBP-20238.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DUSP16
Protein Name dual specificity phosphatase 16
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000228862
InnateDB Gene IDBG-20236 (DUSP16)
Protein Structure
UniProt Annotation
Function Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. {ECO:0000269PubMed:11489891, ECO:0000269PubMed:15888437}.
Subcellular Localization Cytoplasm. Nucleus. Cytoplasmic vesicle. Note=After dissociation upon AGTR stimulation, re-associates with ARRB2 on endocytic vesicles.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0045087 innate immune response (InnateDB)
GO:0045204 MAPK export from nucleus
GO:0045209 MAPK phosphatase export from nucleus, leptomycin B sensitive
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016023 cytoplasmic membrane-bounded vesicle
Protein Structure and Domains
PDB ID
InterPro IPR001763 Rhodanese-like domain
IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
PFAM PF00581
PRINTS PR01764
PIRSF PIRSF000939
SMART SM00450
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BY84
PhosphoSite PhosphoSite-Q9BY84
TrEMBL Q96QS2
UniProt Splice Variant
Entrez Gene 80824
UniGene Hs.536535
RefSeq
HUGO HGNC:17909
OMIM 607175
CCDS
HPRD 09525
IMGT
EMBL AB051487 AB052156 AC007619 AC092824 AF506796 AY038927 BC109235
GenPept AAI09236 AAK69770 AAN75120 BAB21791 BAB40814

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca