InnateDB Protein
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IDBP-20169.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC25A11
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Protein Name
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solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
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Synonyms
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OGC; SLC20A4;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000225665
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InnateDB Gene
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IDBG-20165 (SLC25A11)
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Protein Structure
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Function |
Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.
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Subcellular Localization |
Mitochondrion inner membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
28
[view]
|
Protein-Protein |
26
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR018108
Mitochondrial substrate/solute carrier
IPR023395
Mitochondrial carrier domain
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PFAM |
PF00153
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q02978
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PhosphoSite |
PhosphoSite-Q02978
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TrEMBL |
Q6IBH0
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UniProt Splice Variant |
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Entrez Gene |
8402
|
UniGene |
Hs.184877
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RefSeq |
NP_003553
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HUGO |
HGNC:10981
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OMIM |
604165
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CCDS |
CCDS11059
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HPRD |
05003
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IMGT |
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EMBL |
AC004771
AF070548
AK290376
BC006508
BC006519
BC016294
BC017170
CH471108
CR456834
X66114
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GenPept |
AAC28637
AAH06508
AAH06519
AAH16294
AAH17170
BAF83065
CAA46905
CAG33115
EAW90390
EAW90392
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