InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPAT

Summary

InnateDB Protein

IDBP-20013.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPAT

Protein Name

phosphoribosyl pyrophosphate amidotransferase

Synonyms

ATASE; GPAT; PRAT;

Species

Homo sapiens

Ensembl Protein

ENSP00000264220

InnateDB Gene

IDBG-20011 (PPAT)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitously expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004044	amidophosphoribosyltransferase activity
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001822	kidney development
GO:0006144	purine nucleobase metabolic process
GO:0006164	purine nucleotide biosynthetic process
GO:0006189	'de novo' IMP biosynthetic process
GO:0006543	glutamine catabolic process
GO:0007595	lactation
GO:0008152	metabolic process
GO:0009113	purine nucleobase biosynthetic process
GO:0009116	nucleoside metabolic process
GO:0009168	purine ribonucleoside monophosphate biosynthetic process
GO:0019693	ribose phosphate metabolic process
GO:0031100	organ regeneration
GO:0032869	cellular response to insulin stimulus
GO:0035690	cellular response to drug
GO:0042493	response to drug
GO:0044281	small molecule metabolic process
GO:0051289	protein homotetramerization
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0060135	maternal process involved in female pregnancy

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000583 Class II glutamine amidotransferase domain
IPR000836 Phosphoribosyltransferase domain
IPR005854 Amidophosphoribosyl transferase
IPR029055 Nucleophile aminohydrolases, N-terminal
IPR029057 Phosphoribosyltransferase-like

PFAM

PF00310
PF13537
PF00156

PRINTS

PIRSF

PIRSF000485

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q06203