InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNNI2

Summary

InnateDB Protein

IDBP-19977.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNNI2

Protein Name

troponin I type 2 (skeletal, fast)

Synonyms

AMCD2B; DA2B; FSSV; fsTnI;

Species

Homo sapiens

Ensembl Protein

ENSP00000371331

InnateDB Gene

IDBG-19973 (TNNI2)

Protein Structure

UniProt Annotation

Function

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Subcellular Localization

Disease Associations

Arthrogryposis, distal, 2B (DA2B) [MIM:601680]: A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA2B is characterized by contractures of the hands and feet, and a distinctive face characterized by prominent nasolabial folds, small mouth and downslanting palpebral fissures. {ECO:0000269PubMed:12592607}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0031014	troponin T binding

Biological Process

GO:0003009	skeletal muscle contraction
GO:0006937	regulation of muscle contraction
GO:0030049	muscle filament sliding
GO:0045893	positive regulation of transcription, DNA-templated