Version 5.4
Mus musculus Protein: Vps18
Summary
InnateDB Protein IDBP-199232.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vps18
Protein Name vacuolar protein sorting 18 (yeast)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000036915
InnateDB Gene IDBG-199230 (Vps18)
Protein Structure
UniProt Annotation
Function May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. {ECO:0000250}.
Subcellular Localization Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006886 intracellular protein transport
GO:0007032 endosome organization
GO:0007040 lysosome organization
GO:0016192 vesicle-mediated transport
GO:0046718 viral entry into host cell
Cellular Component
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005884 actin filament
GO:0030897 HOPS complex
GO:0031902 late endosome membrane
Protein Structure and Domains
PDB ID MGI:2443626
InterPro IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
IPR007810 Pep3/Vps18/deep orange
PFAM PF00637
PF05131
PRINTS
PIRSF
SMART SM00299
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R307
PhosphoSite PhosphoSite-Q8R307
TrEMBL Q69ZI9
UniProt Splice Variant
Entrez Gene 228545
UniGene Mm.403856
RefSeq NP_758473
MGI ID
MGI Symbol Vps18
OMIM
CCDS CCDS16599
HPRD
IMGT
EMBL AK029109 AK033333 AK036915 AK173179 BC026870 BC036129 BC039176
GenPept AAH26870 AAH36129 AAH39176 BAC26302 BAC28236 BAC29637 BAD32457

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca