InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Med31

Summary

InnateDB Protein

IDBP-196400.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Med31

Protein Name

mediator of RNA polymerase II transcription, subunit 31 homolog (yeast)

Synonyms

3110004H13Rik; CGI-125; l11Jus15;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021157

InnateDB Gene

IDBG-196398 (Med31)

Protein Structure

UniProt Annotation

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0005515	protein binding
GO:0032403	protein complex binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006461	protein complex assembly
GO:0048147	negative regulation of fibroblast proliferation
GO:0060173	limb development

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016592	mediator complex

Protein Structure and Domains

PDB ID

MGI:1914529

InterPro

IPR008831 Mediator complex, subunit Med31

PFAM

PF05669

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CXU1

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

67279

UniGene

RefSeq

NP_080344

MGI ID

MGI Symbol

Med31

OMIM

CCDS

CCDS24981

HPRD

IMGT

EMBL

AK005655 AK013990 BC019685 BC051929 BX119911

GenPept

AAH19685 AAH51929 BAB24169 BAB29102 CAI24479