Version 5.4
Homo sapiens Protein: IGSF6
Summary
InnateDB Protein IDBP-19354.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGSF6
Protein Name immunoglobulin superfamily, member 6
Synonyms DORA;
Species Homo sapiens
Ensembl Protein ENSP00000268389
InnateDB Gene IDBG-19352 (IGSF6)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in peripheral blood lymphocytes, spleen and lymph node, with low levels in thymus, bone marrow and fetal liver. No expression in non-immune tissues. {ECO:0000269PubMed:9809579}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR003596 Immunoglobulin V-set, subgroup
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00406
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95976
PhosphoSite PhosphoSite-O95976
TrEMBL
UniProt Splice Variant
Entrez Gene 10261
UniGene Hs.671627
RefSeq NP_005840
HUGO HGNC:5953
OMIM 606222
CCDS CCDS10599
HPRD 06938
IMGT
EMBL AJ223183 BC017844
GenPept AAH17844 CAA11155

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca