InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AK7

Summary

InnateDB Protein

IDBP-19193.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AK7

Protein Name

adenylate kinase 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000267584

InnateDB Gene

IDBG-19191 (AK7)

Protein Structure

UniProt Annotation

Function

Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function. {ECO:0000269PubMed:21080915, ECO:0000269PubMed:23416111}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:21080915}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004017	adenylate kinase activity
GO:0004127	cytidylate kinase activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0005524	ATP binding

Biological Process

GO:0002437	inflammatory response to antigenic stimulus
GO:0003351	epithelial cilium movement
GO:0006165	nucleoside diphosphate phosphorylation
GO:0007283	spermatogenesis
GO:0007420	brain development
GO:0009142	nucleoside triphosphate biosynthetic process
GO:0030030	cell projection organization
GO:0035082	axoneme assembly