InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ltbr

Summary

InnateDB Protein

IDBP-189790.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ltbr

Protein Name

lymphotoxin B receptor

Synonyms

AI256028; CD18; Ltar; LTbetaR; TNF-R-III; Tnfbr; TNFCR; TNFR-RP; TNFR2-RP; TNFRrp; Tnfrsf3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032489

InnateDB Gene

IDBG-189788 (Ltbr)

Protein Structure

UniProt Annotation

Function

Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding

Biological Process

GO:0006915	apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0046330	positive regulation of JNK cascade
GO:0048535	lymph node development
GO:0071260	cellular response to mechanical stimulus
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway