InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fgfrl1

Summary

InnateDB Protein

IDBP-188645.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fgfrl1

Protein Name

fibroblast growth factor receptor-like 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000013633

InnateDB Gene

IDBG-188643 (Fgfrl1)

Protein Structure

UniProt Annotation

Function

Has a negative effect on cell proliferation. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in the kidney, brain and lung. Weakly expressed in the muscle, thymus, lymph node, stomach, intestine, colon and liver. Expressed in fetal cartilaginous structures like the nasal cartilage, the ribs and the sternum as well as in the cartilaginous rudiments of developing bones such as the vertebrae and the pelvic bone. High expression is found in the muscles of the tongue and the diaphragm. {ECO:0000269PubMed:11418238, ECO:0000269PubMed:12813049}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001571	non-tyrosine kinase fibroblast growth factor receptor activity
GO:0005007	fibroblast growth factor-activated receptor activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0017134	fibroblast growth factor binding

Biological Process

GO:0001501	skeletal system development
GO:0003179	heart valve morphogenesis
GO:0007166	cell surface receptor signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
GO:0060412	ventricular septum morphogenesis
GO:0060539	diaphragm development

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane

Protein Structure and Domains

PDB ID

MGI:2150920

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91V87