InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDH2

Summary

InnateDB Protein

IDBP-1875.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDH2

Protein Name

cadherin 2, type 1, N-cadherin (neuronal)

Synonyms

CD325; CDHN; CDw325; NCAD;

Species

Homo sapiens

Ensembl Protein

ENSP00000269141

InnateDB Gene

IDBG-1873 (CDH2)

Protein Structure

UniProt Annotation

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	67 [view]
Protein-Protein	66 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0019903	protein phosphatase binding
GO:0045294	alpha-catenin binding
GO:0045295	gamma-catenin binding

Biological Process

GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0016339	calcium-dependent cell-cell adhesion
GO:0016477	cell migration
GO:0034329	cell junction assembly
GO:0034332	adherens junction organization
GO:0042692	muscle cell differentiation
GO:0043410	positive regulation of MAPK cascade
GO:0045216	cell-cell junction organization
GO:0048514	blood vessel morphogenesis
GO:0051146	striated muscle cell differentiation
GO:0051149	positive regulation of muscle cell differentiation
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0005913	cell-cell adherens junction
GO:0005916	fascia adherens
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016342	catenin complex
GO:0030027	lamellipodium
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome