Version 5.4
Homo sapiens Protein: RABGEF1
Summary
InnateDB Protein IDBP-18695.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RABGEF1
Protein Name RAB guanine nucleotide exchange factor (GEF) 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000284957
InnateDB Gene IDBG-18687 (RABGEF1)
Protein Structure
UniProt Annotation
Function Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12505986}. Early endosome {ECO:0000269PubMed:12505986}. Recycling endosome {ECO:0000269PubMed:12505986}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0017112 Rab guanyl-nucleotide exchange factor activity
Biological Process
GO:0006897 endocytosis
GO:0015031 protein transport
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0005769 early endosome
GO:0055037 recycling endosome
Protein Structure and Domains
PDB ID
InterPro IPR002653 Zinc finger, A20-type
IPR003123 Vacuolar sorting protein 9
IPR013995 Vacuolar sorting protein 9, subgroup
PFAM PF01754
PF02204
PRINTS
PIRSF
SMART SM00259
SM00167
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UJ41
PhosphoSite PhosphoSite-Q9UJ41
TrEMBL C9JDA2
UniProt Splice Variant
Entrez Gene 27342
UniGene
RefSeq NP_055319
HUGO HGNC:17676
OMIM 609700
CCDS CCDS5535
HPRD 13770
IMGT
EMBL AC027644 AC079588 AJ250042 AK001702 AK127790 AK223329 AK303006 BC015330 BT007107 CH471140 DQ230533 DQ230534
GenPept AAH15330 AAP35771 AAQ93362 ABA64473 ABA64474 BAC87138 BAD97049 BAG50963 BAG64139 CAB57359 EAX07914 EAX07916

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca