InnateDB Protein
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IDBP-18548.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LNX1
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Protein Name
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ligand of numb-protein X 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000302879
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InnateDB Gene
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IDBG-18546 (LNX1)
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Protein Structure
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Function |
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65 (By similarity). {ECO:0000250}.Isoform 2 provides an endocytic scaffold for IGSF5/JAM4. {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in heart, placenta, kidney, pancreas and brain. {ECO:0000269PubMed:11521506}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 173 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
173
[view]
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Protein-Protein |
173
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001478
PDZ domain
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PFAM |
PF00595
PF13180
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PRINTS |
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PIRSF |
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SMART |
SM00228
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TIGRFAMs |
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Modification |
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SwissProt |
Q8TBB1
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PhosphoSite |
PhosphoSite-Q8TBB1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
84708
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UniGene |
Hs.629493
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RefSeq |
NP_116011
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HUGO |
HGNC:6657
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OMIM |
609732
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CCDS |
CCDS3492
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HPRD |
17287
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IMGT |
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EMBL |
AC058822
AC095040
AF237782
AK056823
AY358326
BC022983
BC034737
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GenPept |
AAH22983
AAH34737
AAK15039
AAQ88692
AAY41000
BAB71291
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