Version 5.4
Homo sapiens Protein: ASL
Summary
InnateDB Protein IDBP-18490.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASL
Protein Name argininosuccinate lyase
Synonyms ASAL;
Species Homo sapiens
Ensembl Protein ENSP00000370219
InnateDB Gene IDBG-18570 (ASL)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004056 argininosuccinate lyase activity
Biological Process
GO:0000050 urea cycle
GO:0006475 internal protein amino acid acetylation
GO:0006527 arginine catabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0042450 arginine biosynthetic process via ornithine
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000362 Fumarate lyase family
IPR008948 L-Aspartase-like
IPR009049 Argininosuccinate lyase
IPR022761 Fumarate lyase, N-terminal
PFAM PF00206
PRINTS PR00149
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P04424
PhosphoSite PhosphoSite-P04424
TrEMBL
UniProt Splice Variant
Entrez Gene 435
UniGene Hs.632015
RefSeq NP_001020117
HUGO HGNC:746
OMIM 608310
CCDS CCDS47598
HPRD 01948
IMGT
EMBL AC068533 AF376770 BC008195 BC033146 J03058 M14218 M21006 M21007 M57638 Y00753
GenPept AAA35566 AAA51786 AAA51787 AAA51788 AAH08195 AAH33146 AAL57276 CAA68722

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca