InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Onecut1

Summary

InnateDB Protein

IDBP-184610.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Onecut1

Protein Name

one cut domain, family member 1

Synonyms

D9Ertd423e; Hfh12; HNF-6; Hnf6; Hnf6b; OC-1; Oc1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058020

InnateDB Gene

IDBG-184608 (Onecut1)

Protein Structure

UniProt Annotation

Function

Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. Stimulates the expression of Onecut3 in the developing endoderm. {ECO:0000269PubMed:15381696}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 222 interaction(s) predicted by orthology.

Predicted by orthology
Total	222 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001889	liver development
GO:0001952	regulation of cell-matrix adhesion
GO:0002064	epithelial cell development
GO:0006006	glucose metabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007492	endoderm development
GO:0009653	anatomical structure morphogenesis
GO:0030154	cell differentiation
GO:0030183	B cell differentiation
GO:0030335	positive regulation of cell migration
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031016	pancreas development
GO:0031018	endocrine pancreas development
GO:0042384	cilium assembly
GO:0045165	cell fate commitment
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048536	spleen development