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InnateDB Protein
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IDBP-183751.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Il17ra
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Protein Name
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interleukin 17 receptor A
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Synonyms
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AW538159; Cdw217; Il17r; VDw217;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000002976
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InnateDB Gene
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IDBG-183749 (Il17ra)
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Protein Structure
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| Function |
Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:21993848}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
19
[view]
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| Protein-Protein |
10
[view]
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| Protein-DNA |
9
[view]
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
15 [view]
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Molecular Function |
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| Biological Process |
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GO:0032747
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positive regulation of interleukin-23 production
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GO:0071345
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cellular response to cytokine stimulus
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GO:0072537
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fibroblast activation
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GO:1900017
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positive regulation of cytokine production involved in inflammatory response
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| Cellular Component |
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| PDB ID |
MGI:107399
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| InterPro |
IPR013568
SEFIR
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| PFAM |
PF08357
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q60943
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| PhosphoSite |
PhosphoSite-Q60943
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
16172
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| UniGene |
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| RefSeq |
NP_032385
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| MGI ID |
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| MGI Symbol |
Il17ra
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| OMIM |
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| CCDS |
CCDS20482
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| HPRD |
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| IMGT |
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| EMBL |
U31993
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| GenPept |
AAC52357
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Version 5.4