InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WASF3

Summary

InnateDB Protein

IDBP-17885.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WASF3

Protein Name

WAS protein family, member 3

Synonyms

Brush-1; SCAR3; WAVE3;

Species

Homo sapiens

Ensembl Protein

ENSP00000335055

InnateDB Gene

IDBG-17879 (WASF3)

Protein Structure

UniProt Annotation

Function

Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269PubMed:17623672, ECO:0000269PubMed:21834987}.

Subcellular Localization

Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Expressed in ovary and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding

Biological Process

GO:0006461	protein complex assembly
GO:0007010	cytoskeleton organization
GO:0008360	regulation of cell shape
GO:0014003	oligodendrocyte development
GO:0030032	lamellipodium assembly
GO:0030041	actin filament polymerization
GO:0031643	positive regulation of myelination