InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DDX24

Summary

InnateDB Protein

IDBP-17856.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX24

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 24

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000328690

InnateDB Gene

IDBG-17852 (DDX24)

Protein Structure

UniProt Annotation

Function

ATP-dependent RNA helicase. {ECO:0000305}.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous. Most abundant in heart and brain, but with lowest levels in thymus and small intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003724	RNA helicase activity
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0016070	RNA metabolic process

Cellular Component

GO:0005730	nucleolus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9GZR7