Version 5.4
Homo sapiens Protein: GDE1
Summary
InnateDB Protein IDBP-17769.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GDE1
Protein Name glycerophosphodiester phosphodiesterase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000261386
InnateDB Gene IDBG-17765 (GDE1)
Protein Structure
UniProt Annotation
Function Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Perinuclear vesicles and cell membrane. {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:10760272}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008081 phosphoric diester hydrolase activity
GO:0008889 glycerophosphodiester phosphodiesterase activity
GO:0046872 metal ion binding
GO:0047395 glycerophosphoinositol glycerophosphodiesterase activity
Biological Process
GO:0006071 glycerol metabolic process
GO:0006629 lipid metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NZC3
PhosphoSite PhosphoSite-
TrEMBL H3BNA5
UniProt Splice Variant
Entrez Gene 51573
UniGene Hs.623801
RefSeq NP_057725
HUGO HGNC:29644
OMIM 605943
CCDS CCDS10578
HPRD 12070
IMGT
EMBL AC003108 AC012621 AC130456 AF212862 AY463154 BC014981 BC025273 CH471186 U91321
GenPept AAC05440 AAC05803 AAF65234 AAH14981 AAH25273 AAR25624 EAW50283 EAW50286

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca