InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPLAD1

Summary

InnateDB Protein

IDBP-17548.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPLAD1

Protein Name

protein tyrosine phosphatase-like A domain containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000261875

InnateDB Gene

IDBG-17546 (PTPLAD1)

Protein Structure

UniProt Annotation

Function

Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis. Involved in Rac1-signaling pathways leading to the modulation of gene expression. {ECO:0000269PubMed:10747961, ECO:0000269PubMed:18554506}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:18554506}; Multi-pass membrane protein {ECO:0000269PubMed:18554506}.

Disease Associations

Tissue Specificity

Highly expressed in testis, kidney, brain, liver and weakly in skeletal muscle, spleen and heart. No expression detected in leukocytes. {ECO:0000269PubMed:10747961, ECO:0000269PubMed:18554506}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0016829	lyase activity

Biological Process

GO:0006633	fatty acid biosynthetic process
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0007254	JNK cascade
GO:0007257	activation of JUN kinase activity
GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0016601	Rac protein signal transduction
GO:0043547	positive regulation of GTPase activity