InnateDB Protein
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IDBP-175041.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pias1
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Protein Name
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protein inhibitor of activated STAT 1
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Synonyms
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2900068C24Rik; Ddxbp1; GBP;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000096248
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InnateDB Gene
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IDBG-175037 (Pias1)
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Protein Structure
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Function |
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA (By similarity). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. {ECO:0000250, ECO:0000269PubMed:22406621}.
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Subcellular Localization |
Nucleus speckle {ECO:0000250}. Nucleus, PML body {ECO:0000269PubMed:12077349, ECO:0000269PubMed:22406621}. Note=Interaction with CSRP2 may induce a partial redistribution along the cytoskeleton. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in kidney, heart, spleen, brain and cerebellum; weak expression, if any, in liver and lung. {ECO:0000269PubMed:10854042}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 86 interaction(s) predicted by orthology.
Experimentally validated |
Total |
45
[view]
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Protein-Protein |
45
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
86 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006351
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transcription, DNA-templated
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GO:0007259
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JAK-STAT cascade
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GO:0007283
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spermatogenesis
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GO:0016925
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protein sumoylation
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GO:0032436
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positive regulation of proteasomal ubiquitin-dependent protein catabolic process
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GO:0033235
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positive regulation of protein sumoylation
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GO:0042127
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regulation of cell proliferation
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0051152
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positive regulation of smooth muscle cell differentiation
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GO:0065004
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protein-DNA complex assembly
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Cellular Component |
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PDB ID |
MGI:1913125
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InterPro |
IPR003034
SAP domain
IPR004181
Zinc finger, MIZ-type
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PFAM |
PF02037
PF02891
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PRINTS |
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PIRSF |
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SMART |
SM00513
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TIGRFAMs |
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Modification |
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SwissProt |
O88907
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PhosphoSite |
PhosphoSite-O88907
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TrEMBL |
Q2M4G9
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UniProt Splice Variant |
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Entrez Gene |
56469
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UniGene |
Mm.490317
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RefSeq |
NP_062637
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MGI ID |
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MGI Symbol |
Pias1
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OMIM |
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CCDS |
CCDS40665
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HPRD |
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IMGT |
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EMBL |
AF077950
AK075708
AY902346
BC051417
CH466522
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GenPept |
AAC36701
AAH51417
AAY21056
BAC35902
EDL26033
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