Version 5.4
Homo sapiens Protein: SLAIN2
Summary
InnateDB Protein IDBP-17422.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLAIN2
Protein Name SLAIN motif family, member 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000264313
InnateDB Gene IDBG-17420 (SLAIN2)
Protein Structure
UniProt Annotation
Function Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269PubMed:21646404}.
Subcellular Localization Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. Detected at the plus end of growing microtubules.
Disease Associations
Tissue Specificity Widely expressed with highest levels in adult liver, testis and ovary, and lowest levels in adult pancreas and spleen and in fetal brain. {ECO:0000269PubMed:10819331}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007020 microtubule nucleation
GO:0031113 regulation of microtubule polymerization
GO:0031116 positive regulation of microtubule polymerization
GO:0031122 cytoplasmic microtubule organization
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0015630 microtubule cytoskeleton
GO:0035371 microtubule plus-end
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P270
PhosphoSite PhosphoSite-Q9P270
TrEMBL A0A024R9T6
UniProt Splice Variant
Entrez Gene 57606
UniGene Hs.604784
RefSeq NP_065897
HUGO HGNC:29282
OMIM 610492
CCDS CCDS47051
HPRD
IMGT
EMBL AB040891 AK291006 BC031691 CH471069
GenPept AAH31691 BAA95982 BAF83695 EAW93057 EAW93058

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca