Mus musculus Protein: Adamts5 | |||||||||||
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Summary | |||||||||||
InnateDB Protein | IDBP-173254.6 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | Adamts5 | ||||||||||
Protein Name | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) | ||||||||||
Synonyms | 9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11; AI481094; ASMP-2; | ||||||||||
Species | Mus musculus | ||||||||||
Ensembl Protein | ENSMUSP00000023611 | ||||||||||
InnateDB Gene | IDBG-173252 (Adamts5) | ||||||||||
Protein Structure | |||||||||||
UniProt Annotation | |||||||||||
Function | Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period. | ||||||||||
Subcellular Localization | Secreted, extracellular space, extracellular matrix {ECO:0000250}. | ||||||||||
Disease Associations | |||||||||||
Tissue Specificity | |||||||||||
Comments | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||
PDB ID | MGI:1346321 | ||||||||||
InterPro |
IPR000884
Thrombospondin, type 1 repeat IPR001590 Peptidase M12B, ADAM/reprolysin IPR002870 Peptidase M12B, propeptide IPR006586 ADAM, cysteine-rich IPR010294 ADAM-TS Spacer 1 IPR013273 Peptidase M12B, ADAM-TS IPR013276 Peptidase M12B, ADAM-TS5 |
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PFAM |
PF00090
PF01421 PF01562 PF08516 PF05986 |
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PRINTS |
PR01857
PR01860 |
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PIRSF | |||||||||||
SMART |
SM00209
SM00608 |
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TIGRFAMs | |||||||||||
Post-translational Modifications | |||||||||||
Modification | |||||||||||
Cross-References | |||||||||||
SwissProt | Q9R001 | ||||||||||
PhosphoSite | PhosphoSite- | ||||||||||
TrEMBL | Q8BGP4 | ||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 23794 | ||||||||||
UniGene | Mm.456348 | ||||||||||
RefSeq | NP_035912 | ||||||||||
MGI ID | |||||||||||
MGI Symbol | Adamts5 | ||||||||||
OMIM | |||||||||||
CCDS | CCDS28288 | ||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | AF140673 AK044746 AK082475 BC138619 BC138620 | ||||||||||
GenPept | AAD56356 AAI38620 AAI38621 BAC32062 BAC38503 | ||||||||||