InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd276

Summary

InnateDB Protein

IDBP-172082.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd276

Protein Name

CD276 antigen

Synonyms

6030411F23Rik; AU016588; B7h3; B7RP-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042681

InnateDB Gene

IDBG-172080 (Cd276)

Protein Structure

UniProt Annotation

Function

Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. Plays a positive regulatory role in bone formation and has a dual role in the bone-immune interface. Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells. {ECO:0000269PubMed:12055244, ECO:0000269PubMed:12925852, ECO:0000269PubMed:12939639, ECO:0000269PubMed:15294965, ECO:0000269PubMed:15682454}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:12055244}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0030501	positive regulation of bone mineralization
GO:0042102	positive regulation of T cell proliferation
GO:0042110	T cell activation
GO:0042130	negative regulation of T cell proliferation
GO:0045077	negative regulation of interferon-gamma biosynthetic process
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0045085	negative regulation of interleukin-2 biosynthetic process
GO:0045669	positive regulation of osteoblast differentiation
GO:0050728	negative regulation of inflammatory response
GO:0050776	regulation of immune response
GO:1900042	positive regulation of interleukin-2 secretion

Cellular Component

GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2183926

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003597 Immunoglobulin C1-set
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07654
PF07686
PF08205

PRINTS

PIRSF

SMART

SM00406
SM00407
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8VE98