InnateDB Protein
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IDBP-170968.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Palm
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Protein Name
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paralemmin
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000040596
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InnateDB Gene
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IDBG-170966 (Palm)
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Protein Structure
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Function |
Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:0000269PubMed:18287537}.
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Subcellular Localization |
Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, filopodium membrane; Lipid-anchor. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine. Basolateral cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Apicolateral cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Translocation to the plasma membrane is enhanced upon stimulation of neuronal activity. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expression is highest in brain, intermediate in adrenal gland and kidney, and much lower or undetectable in other tissues. Isoform 1 is the predominant isoform in most tissues except brain and kidney where isoform 2 predominates. {ECO:0000269PubMed:9813098}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1261814
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InterPro |
IPR004965
Paralemmin
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PFAM |
PF03285
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Z0P4
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PhosphoSite |
PhosphoSite-Q9Z0P4
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TrEMBL |
Q6ZQE7
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UniProt Splice Variant |
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Entrez Gene |
18483
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UniGene |
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RefSeq |
NP_075617
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MGI ID |
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MGI Symbol |
Palm
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OMIM |
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CCDS |
CCDS23991
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HPRD |
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IMGT |
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EMBL |
AK129107
Y14771
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GenPept |
BAC97917
CAB37403
CAB37404
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