InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Yy1

Summary

InnateDB Protein

IDBP-170896.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Yy1

Protein Name

YY1 transcription factor

Synonyms

AW488674; NF-E1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021692

InnateDB Gene

IDBG-170894 (Yy1)

Protein Structure

UniProt Annotation

Function

Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. Binds to the upstream conserved region (UCR) (5'- CGCCATTTT-3') of Moloney murine leukemia virus (MuLV). Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'- GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (PubMed:15329343). Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Involved in spermatogenesis and may play a role in meiotic DNA double-strand break repair. {ECO:0000269PubMed:15329343, ECO:0000269PubMed:18026119, ECO:0000269PubMed:19786570}.Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. {ECO:0000250}.

Subcellular Localization

Nucleus matrix {ECO:0000269PubMed:19786570}. Note=Associated with the nuclear matrix. In testis, localized to heterochromatin of spermatocytes.

Disease Associations

Tissue Specificity

Expressed in ovary and, at lower levels, in testis. {ECO:0000269PubMed:18024232}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 110 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	24 [view]
Protein-DNA	9 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	110 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000400	four-way junction DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000724	double-strand break repair via homologous recombination
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006403	RNA localization
GO:0006974	cellular response to DNA damage stimulus
GO:0007283	spermatogenesis
GO:0009952	anterior/posterior pattern specification
GO:0010225	response to UV-C
GO:0030154	cell differentiation
GO:0034644	cellular response to UV
GO:0034696	response to prostaglandin F
GO:0045087	innate immune response (InnateDB)
GO:0048593	camera-type eye morphogenesis
GO:0051276	chromosome organization

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005886	plasma membrane
GO:0016363	nuclear matrix
GO:0031011	Ino80 complex
GO:0031519	PcG protein complex