InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC51B

Summary

InnateDB Protein

IDBP-16990.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC51B

Protein Name

Organic solute transporter subunit beta

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000335292

InnateDB Gene

IDBG-16988 (SLC51B)

Protein Structure

UniProt Annotation

Function

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities. {ECO:0000269PubMed:16317684}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12719432, ECO:0000269PubMed:16317684}; Single-pass membrane protein {ECO:0000269PubMed:12719432, ECO:0000269PubMed:16317684}. Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes.

Disease Associations

Tissue Specificity

Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat. {ECO:0000269PubMed:12719432, ECO:0000269PubMed:16317684}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006810	transport
GO:0015721	bile acid and bile salt transport
GO:0031647	regulation of protein stability
GO:0060050	positive regulation of protein glycosylation
GO:0070863	positive regulation of protein exit from endoplasmic reticulum
GO:0090314	positive regulation of protein targeting to membrane