Version 5.4
Homo sapiens Protein: CABYR
Summary
InnateDB Protein IDBP-1690.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CABYR
Protein Name calcium binding tyrosine-(Y)-phosphorylation regulated
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000317095
InnateDB Gene IDBG-1684 (CABYR)
Protein Structure
UniProt Annotation
Function May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.
Subcellular Localization Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Note=Localized to fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella.Isoform 1: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.Isoform 3: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.Isoform 5: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.
Disease Associations
Tissue Specificity Expressed in elongating spermatids and spermatozoa (at protein level). Isoform 1 is expressed in testis. Isoform 3 and isoform 5 are also expressed in brain, pancreas and numerous brain tumors. {ECO:0000269PubMed:11820818, ECO:0000269PubMed:15752768, ECO:0000269PubMed:16139264}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0017124 SH3 domain binding
GO:0019899 enzyme binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0003351 epithelial cilium movement
GO:0048240 sperm capacitation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0031514 motile cilium
GO:0035686 sperm fibrous sheath
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75952
PhosphoSite PhosphoSite-O75952
TrEMBL J3QQK7
UniProt Splice Variant
Entrez Gene 26256
UniGene Hs.511983
RefSeq NP_619584
HUGO HGNC:15569
OMIM 612135
CCDS CCDS11883
HPRD 10806
IMGT
EMBL AC090772 AF088868 AF295037 AF295038 AF295039 AF329634 AK313243 AY007205 BC011996 CH471088
GenPept AAC35373 AAG01891 AAG17889 AAG17890 AAG17891 AAH11996 AAL56051 BAG36054 EAX01177

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca