InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Isx

Summary

InnateDB Protein

IDBP-168735.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Isx

Protein Name

intestine specific homeobox

Synonyms

9130012O13Rik; Pix-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034034

InnateDB Gene

IDBG-168733 (Isx)

Protein Structure

UniProt Annotation

Function

Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCMO1 expression in the intestine. {ECO:0000269PubMed:16971476, ECO:0000269PubMed:18093975}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Expressed in intestinal epithelial cells from the duodenum to the proximal colon. {ECO:0000269PubMed:16971476, ECO:0000269PubMed:18093975}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:1901738	regulation of vitamin A metabolic process