Version 5.4
Mus musculus Protein: Cyp19a1
Summary
InnateDB Protein IDBP-166388.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cyp19a1
Protein Name cytochrome P450, family 19, subfamily a, polypeptide 1
Synonyms Ar; ArKO; Cyp19; Int-5; Int5; p450arom;
Species Mus musculus
Ensembl Protein ENSMUSP00000034811
InnateDB Gene IDBG-166386 (Cyp19a1)
Protein Structure
UniProt Annotation
Function Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Subcellular Localization Membrane; Peripheral membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0020037 heme binding
GO:0070330 aromatase activity
Biological Process
GO:0008209 androgen metabolic process
GO:0055114 oxidation-reduction process
GO:0060736 prostate gland growth
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:88587
InterPro IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
PFAM PF00067
PRINTS PR00385
PR00463
PR00465
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P28649
PhosphoSite PhosphoSite-P28649
TrEMBL Q3ZAT3
UniProt Splice Variant
Entrez Gene 13075
UniGene Mm.5199
RefSeq NP_031836
MGI ID
MGI Symbol Cyp19a1
OMIM
CCDS CCDS23187
HPRD
IMGT
EMBL AK143323 BC103670 BC104489 CH466522 D00659 FJ619058 FJ619059 FJ619060
GenPept AAI03671 AAI04490 ACP43527 ACP43528 ACP43529 BAA00551 BAE25342 EDL25809

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca