Version 5.4
Mus musculus Protein: Smek1
Summary
InnateDB Protein IDBP-164834.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smek1
Protein Name SMEK homolog 1, suppressor of mek1 (Dictyostelium)
Synonyms 1110034C04Rik; BC064465; mKIAA2010;
Species Mus musculus
Ensembl Protein ENSMUSP00000041667
InnateDB Gene IDBG-164832 (Smek1)
Protein Structure
UniProt Annotation
Function Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000250}. Note=In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0045722 positive regulation of gluconeogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0030289 protein phosphatase 4 complex
Protein Structure and Domains
PDB ID MGI:1915984
InterPro IPR006887 Domain of unknown function DUF625
IPR016024 Armadillo-type fold
PFAM PF04802
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P2K6
PhosphoSite PhosphoSite-Q6P2K6
TrEMBL
UniProt Splice Variant
Entrez Gene 68734
UniGene Mm.401594
RefSeq NP_997594
MGI ID
MGI Symbol Smek1
OMIM
CCDS CCDS26111
HPRD
IMGT
EMBL AK051239 AK148868 AK156272 AK173331 BC044817 BC064465
GenPept AAH44817 AAH64465 BAC34569 BAD32609 BAE28682 BAE33651

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca