InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CAMK1

Summary

InnateDB Protein

IDBP-16332.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAMK1

Protein Name

calcium/calmodulin-dependent protein kinase I

Synonyms

CAMKI;

Species

Homo sapiens

Ensembl Protein

ENSP00000256460

InnateDB Gene

IDBG-16330 (CAMK1)

Protein Structure

UniProt Annotation

Function

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser- 694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser- 498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen- stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. {ECO:0000250, ECO:0000269PubMed:11114197, ECO:0000269PubMed:12193581, ECO:0000269PubMed:14507913, ECO:0000269PubMed:14754892, ECO:0000269PubMed:17056143, ECO:0000269PubMed:17442826, ECO:0000269PubMed:18184567, ECO:0000269PubMed:20181577}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex. {ECO:0000269PubMed:12193581, ECO:0000269PubMed:17056143}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006913	nucleocytoplasmic transport
GO:0007049	cell cycle
GO:0007165	signal transduction
GO:0010976	positive regulation of neuron projection development
GO:0032880	regulation of protein localization
GO:0043393	regulation of protein binding
GO:0046827	positive regulation of protein export from nucleus
GO:0051147	regulation of muscle cell differentiation
GO:0051149	positive regulation of muscle cell differentiation
GO:0051835	positive regulation of synapse structural plasticity
GO:0060999	positive regulation of dendritic spine development
GO:0071902	positive regulation of protein serine/threonine kinase activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt