InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pdgfb

Summary

InnateDB Protein

IDBP-163250.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdgfb

Protein Name

platelet derived growth factor, B polypeptide

Synonyms

PDGF-B; Sis;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000500

InnateDB Gene

IDBG-163248 (Pdgfb)

Protein Structure

UniProt Annotation

Function

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA. {ECO:0000269PubMed:10734101, ECO:0000269PubMed:14561699, ECO:0000269PubMed:19030102, ECO:0000269PubMed:7958863}.

Subcellular Localization

Secreted. Note=Released by platelets upon wounding. {ECO:0000250}.

Disease Associations

Tissue Specificity

Localized to vascular smooth muscle cells. Also weakly expressed by cortical interstitial cells but absent in tubules. Up-regulated in areas of renal fibrosis. In mice with unilateral ureteral obstruction, an increased expression in interstitial cells and in some tubules observed after day 4. {ECO:0000269PubMed:14514732}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005161	platelet-derived growth factor receptor binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008083	growth factor activity
GO:0016176	superoxide-generating NADPH oxidase activator activity
GO:0042056	chemoattractant activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0048407	platelet-derived growth factor binding

Biological Process

GO:0001568	blood vessel development
GO:0001666	response to hypoxia
GO:0001892	embryonic placenta development
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002548	monocyte chemotaxis
GO:0003104	positive regulation of glomerular filtration
GO:0006260	DNA replication
GO:0006468	protein phosphorylation
GO:0006929	substrate-dependent cell migration
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007507	heart development
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0009611	response to wounding
GO:0010033	response to organic substance
GO:0010512	negative regulation of phosphatidylinositol biosynthetic process
GO:0010544	negative regulation of platelet activation
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014070	response to organic cyclic compound
GO:0014911	positive regulation of smooth muscle cell migration
GO:0016049	cell growth
GO:0018105	peptidyl-serine phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030031	cell projection assembly
GO:0030036	actin cytoskeleton organization
GO:0030335	positive regulation of cell migration
GO:0030336	negative regulation of cell migration
GO:0031954	positive regulation of protein autophosphorylation
GO:0032147	activation of protein kinase activity
GO:0032148	activation of protein kinase B activity
GO:0032355	response to estradiol
GO:0032868	response to insulin
GO:0035793	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0038001	paracrine signaling
GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0042060	wound healing
GO:0042127	regulation of cell proliferation
GO:0042493	response to drug
GO:0043406	positive regulation of MAP kinase activity
GO:0043410	positive regulation of MAPK cascade
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0043627	response to estrogen
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045740	positive regulation of DNA replication
GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045840	positive regulation of mitosis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045907	positive regulation of vasoconstriction
GO:0045908	negative regulation of vasodilation
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048146	positive regulation of fibroblast proliferation
GO:0048514	blood vessel morphogenesis
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918	positive chemotaxis
GO:0050921	positive regulation of chemotaxis
GO:0051781	positive regulation of cell division
GO:0060326	cell chemotaxis
GO:0060445	branching involved in salivary gland morphogenesis
GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060947	cardiac vascular smooth muscle cell differentiation
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071363	cellular response to growth factor stimulus
GO:0071506	cellular response to mycophenolic acid
GO:0072126	positive regulation of glomerular mesangial cell proliferation
GO:0072255	metanephric glomerular mesangial cell development
GO:0072262	metanephric glomerular mesangial cell proliferation involved in metanephros development
GO:0072264	metanephric glomerular endothelium development
GO:0072593	reactive oxygen species metabolic process
GO:0090280	positive regulation of calcium ion import
GO:1900127	positive regulation of hyaluronan biosynthetic process
GO:2000379	positive regulation of reactive oxygen species metabolic process
GO:2000573	positive regulation of DNA biosynthetic process
GO:2000591	positive regulation of metanephric mesenchymal cell migration