Version 5.4
Homo sapiens Protein: VWC2
Summary
InnateDB Protein IDBP-16323.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VWC2
Protein Name von Willebrand factor C domain containing 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000341819
InnateDB Gene IDBG-16321 (VWC2)
Protein Structure
UniProt Annotation
Function BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity). {ECO:0000250}.
Subcellular Localization Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}. Cell junction, synapse {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0010811 positive regulation of cell-substrate adhesion
GO:0030514 negative regulation of BMP signaling pathway
GO:0045666 positive regulation of neuron differentiation
Cellular Component
GO:0005604 basement membrane
GO:0005614 interstitial matrix
GO:0005615 extracellular space
GO:0030054 cell junction
GO:0031012 extracellular matrix
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0045202 synapse
Protein Structure and Domains
PDB ID
InterPro IPR001007 von Willebrand factor, type C
PFAM PF00093
PRINTS
PIRSF
SMART SM00214
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2TAL6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 375567
UniGene Hs.629302
RefSeq NP_940972
HUGO HGNC:30200
OMIM 611108
CCDS CCDS5508
HPRD 18271
IMGT
EMBL AB292671 AY358393 BC110857 CH236955 CH471128
GenPept AAI10858 AAQ88759 BAF51551 EAL23904 EAW60985

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca