InnateDB Protein
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IDBP-162526.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Sun2
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Protein Name
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Sad1 and UNC84 domain containing 2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000086724
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InnateDB Gene
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IDBG-162524 (Sun2)
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Protein Structure
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Function |
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, Syne2 and Sun2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for Rab5-GDP and participate in the activation of Rab5. {ECO:0000269PubMed:16380439, ECO:0000269PubMed:19509342, ECO:0000269PubMed:19843581, ECO:0000269PubMed:19874786, ECO:0000269PubMed:20724637}.
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Subcellular Localization |
Nucleus inner membrane; Single-pass type II membrane protein. Endosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in heart, placenta and muscle. {ECO:0000269PubMed:12393179}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
18 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2443011
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InterPro |
IPR008979
Galactose-binding domain-like
IPR012919
Sad1/UNC-like, C-terminal
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PFAM |
PF07738
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BJS4
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PhosphoSite |
PhosphoSite-Q8BJS4
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TrEMBL |
E0CY39
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UniProt Splice Variant |
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Entrez Gene |
223697
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UniGene |
Mm.489119
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RefSeq |
NP_919323
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MGI ID |
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MGI Symbol |
Sun2
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OMIM |
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CCDS |
CCDS27649
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HPRD |
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IMGT |
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EMBL |
AC118227
AK080116
AK128958
AK156246
AK171058
AY682987
CH466550
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GenPept |
AAT90499
BAC37829
BAC87662
BAE33640
BAE42217
EDL04635
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